INTERNATIONAL BLEST SCIENTIFIC

Regenerative medicine has significantly increased scientific interest in bioactive peptides capable of modulating biological mechanisms associated with musculoskeletal tissue repair. In this context, BPC-157, Thymosin Beta-4 (TB4), TB-500, TB-500 Fragment, and KPV have emerged as molecules of interest due to their potential involvement in angiogenesis, cell migration, inflammatory modulation, and tissue remodeling processes. This study aimed to critically analyze the biological mechanisms and translational potential of these peptides in the context of musculoskeletal regeneration. The research was conducted as an integrative literature review with an applied nature, qualitative approach, and exploratory-descriptive objective. Data collection was performed using internationally recognized scientific databases, including PubMed/MEDLINE, Scopus, Web of Science, and ScienceDirect, relying exclusively on real, verifiable, and indexed references. The findings demonstrated that BPC-157 is primarily associated with angiogenic mechanisms and vascular protection; Thymosin Beta-4 is mainly linked to actin regulation and cell migration; TB-500 and its fragments present more limited evidence requiring further validation; whereas KPV exhibits potential anti-inflammatory activity through modulation of the NF-kB pathway. It is concluded that the investigated peptides present biologically plausible mechanisms and promising experimental findings; however, the consolidation of their clinical use remains dependent on the expansion of controlled and methodologically robust clinical studies.